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Keywords: Type 2 Diabetes Mellitus, Metformin, Vitamin B12 Deficiency, Screening, Disease Management INTRODUCTION Over the past two decades, several studies have highlighted a considerable increase in the risk of vitamin B12 deficiency in patients with type 2 diabetes (T2D) using metformin [1-5]

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Xu, Hou, Li, and colleagues, publishing in Bioengineered in 2022, examined the effect of NNMT on lipid accumulation in 3T3-L1 adipocytes using lentiviral RNAi knockdown (NNMT reduced to approximately 27% of control mRNA) and plasmid-driven overexpression, and found that NNMT knockdown significantly reduced lipid accumulation (1.000 ± 0.004 vs