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Controlled oxygenation rewarming (8–20°C) is the relay process of SCS and HMP, enabling a slow and precisely controlled rewarming of grafts to prevent mitochondrial malfunction and the activation of apoptotic signaling pathways resulting from excessively rapid rewarming (146)

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However, feedback inhibition of important enzymes in their biosynthetic pathways and toxic effects from their excess inhibited cell growth (Lim et al., 2001