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The highest ascorbate concentrations were found in the cytosol (21.7 mM) and peroxisomes (22.8 mM) (Zechmann, 2011

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This central role of neuroglia as the link between central and peripheral inflammation may also apply to the gut-brain axis which has received increasing attention since intestinal microbial dysbiosis, gastrointestinal inflammation and gut barrier dysfunction are noted in ME/CFS, and may account for translocation of bacteria and dietary metabolites across mucosal barriers [for a thoughtful commentary, see (Maes et al., 2007