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A systematic review has recently examined the efficacy of CoQ 10 supplementation in the prevention of cardiovascular disease (CVD) without lifestyle intervention (Flowers et al., 10 in the prevention of complications in patients undergoing cardiac surgery, and the results showed that CoQ 10 therapy lowers the need of inotropic drugs and reduces the appearance of ventricular arrhythmias after surgery (de Frutos et al., Short-term daily treatment (12 weeks or less) with 100 mg CoQ 10 improves left ventricular ejection fraction in patients suffering from heart failure (Fotino et al., 10 was observed on left ventricular ejection fraction or exercise capacity in patients with heart failure (Madmani et al., 2014)
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However, our preliminary study (unpublished) indicates that extracellular ligand-binding domain is required for this EGF receptor transactivation
