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Overexpression of TM6SF2 led to an increase in total cholesterol and LDL cholesterol (LDL-c), and a decrease in HDL-c, while downregulation of TM6SF2 may lead to a decrease in total cholesterol

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Proposed mechanisms include modulation of neurotransmitter systems involved in sleep-wake balance and interaction with neuroendocrine pathways that affect recovery and stress physiology