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The reason that could explain the poor infection outcome of GSH deficient mice is that the GSH:GSSG ratio directly affected the production of IL-12 from macrophages and this caused a reduction of IFN-γ production from NK or T cells, which could in turn activate the microbicidal activity of macrophages to kill the intracellular bacteria [104]

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The concordance (C)-index, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA) were used to assess the prognostic discriminative ability of the nomogram, ALBI grade, MHR, and MHR + ALBI grade