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Duotone berth — harbor brief on the left, coral-folded cargo sheet on the right.
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In the fourth and last stage of B12 deficiency, clinical manifestations are experienced by the individual — including macrocytic anemia (a form of anemia in which red blood cells are larger than usual, hence the term “macro”) and, if left untreated, irreversible neurological damage
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Since warfarin initially decreases protein C levels faster than the coagulation factors, it can paradoxically increase the blood's tendency to coagulate when treatment is first begun (many patients when starting on warfarin are given heparin in parallel to combat this), leading to massive thrombosis with skin necrosis and gangrene of limbs
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