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However, several studies have demonstrated that HNE at nontoxic levels can potently activate stress response pathways such as MAPK and nuclear translocation of a redox-sensitive transcriptional factor, Nrf2 [46]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zhao J., Solano M.M., Oldenburg C.E., Liu T., Wang Y., Wang N., Lin S.C