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For example,a cohort study of depressive patients and healthy controls found that MTHFR polymorphism were more common in the individuals with depression history compared to controls 67 , while a study over a 60-month follow-up with depressed subjects indicated that the CC genotype of MTHFR C677T were more likely to have more severe symptoms compared to TT genotype carriers 68

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doi: 10.1073/pnas.0307888101 [DOI] [PMC free article] [PubMed] [Google Scholar] 88