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Notably, chTLR21-mediated transcription of IFN-β is dependent on both NF-κB and IRF7 signaling pathways, yet it is independent of TBK1 kinase, a distinctive feature that contrasts with mammalian TLR9 signaling ( 4.2 Antioxidant defense Under conditions of oxidative stress, avian erythrocytes demonstrate a substantial antioxidant response