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Interestingly, recent studies have shown that the specific deletion of Fbxw7 (a E3 ubiquitin ligase component) in Schwann cells is sufficient to induce the production of thicker myelin sheaths by these cells, together with a myelination of multiple axons similar to that observed with OLGs (Harty et al., 2019)

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Table 1 summarizes the different antioxidants described and their mechanism of action in protecting against oxidative stress