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The free-living nematode Caenorhabditis elegans has already been established as a model for anthelmintic drug discovery due to its ease of laboratory culture, amenability to HTS for rapid whole-organism phenotypic screening, and the availability of extensive forward and reverse genetic methods 16,17,18

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Signal 4: Nutrients Over the past decade, the existence of a crucial fourth set of signals that regulate T cell function and differentiation has become increasingly apparent – metabolic fuels and nutrients, like glucose, amino acids (AAs) and lipids

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