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Manipulation of intracellular GSH pools by supplementation with GSH precursors was found to block induction of JNK activity by methylating agents [26] Similarly p53 function has been reported to be redox sensitive, primarily through in vitro modification of its cysteine residues [27]

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The Microbiota – A Modulator of Gut Physiology The ENS encompasses vast networks of extrinsic and intrinsic neuronal circuits that independently control endocrine functions, conduct transmucosal fluid movement, and regulate local blood flow and motility via reflex systems (reviewed in Rao and Gershon, 2016)