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This is particularly relevant in patients with compromised immune function or chronic inflammation, where even low-level immunogenicity can lead to anti-drug antibody (ADA) formation and decreased therapeutic efficacy [271]

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The π and μ classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein: protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)