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Conclusion: Severe comorbidity burden is common in MeVO patients and linked to poorer prognosis when compared to patients without comorbidities

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This was accompanied by upregulation of inducible nitric oxide synthase (iNOS), IL-1β, and TNF-α, and downregulation of arginase 1 (Arg-1), IL-10, and transforming growth factor-beta (TGF-β)